Which may damage adolescent’s brain development, e-cigarette use or nicotine?
Dr Vivek Murthy, the US Surgeon General also declares “your kids are not an experiment”. And on this point, Dr Murthy is right because no adolescent human has been involved in clinical studies with nicotine. The animal model used by researchers and on which Surgeon General Murthy elaborates his conclusions is the rodent .
The last US Surgeon General report was limpid on the fact that the e-cigarette shouldn’t be used by teenagers. Nobody seems to contradict scientific conclusions that the use of any nicotine products may also have negative effects on adolescent humans  but everyone wonders why this is put to question right now.
There was a time when more than one-third high school seniors smoked
It is interesting to remember that in 1996, 34% of 12th graders, 30.4% of 10th graders, and 21% of 8th graders smoked within the past 30 days, according the MTF study on drug use from 1975 to 2014. The figures in 2016 were 10.5%, 4.9%, and 2.6%, respectively. Such figures must be compared to vaping that peaked at 16% in 2015 among the senior students . And among those vapers, two-thirds responded “just flavoring” to the question asking what contained their e-liquid when they vaped. Only about 20% of 12th and 10th graders and only 13% of 8th graders answered “nicotine” .
A less hazardous mean of experiencing nicotine?
The FDA’s message fails to disclose that the damage of nicotine delivered by e-cigarettes is the same as that produced by nicotine delivered by combustible tobacco on adolescent brain. The concern should even be greater with kids’ smoking because of the combustion by-products of higher toxicity than the e-cigarette aerosol.
— FDA Tobacco (@FDATobacco) February 15, 2017
 Yuan M., Cross S. J., Loughlin S.E., & Leslie F.M., 2015. Nicotine and the adolescent brain. The Journal of physiology, 593(16), 3397-3412.
 England L.J., Bunnell R.E., Pechacek T.F., Tong V.T., McAfee T.A., 2015. Nicotine and the developing human: a neglected element in the electronic cigarette debate. Am. J. Prev. Med. 49, 286–293, http://dx.doi.org/10.1016/j.amepre.2015.01.015.
 Singh T, Arrazola RA, Corey CG, et al., Centers for Disease Control and Prevention. 2016. Tobacco use among middle and high school students—United States, 2011-2015. MMWR Morb Mortal Wkly Rep.;65(14):361-367.
 Miech R., Patrick M.E., O’Malley P.M., Johnston L.D., 2016. What are kids vaping? Results from a national survey of US adolescents. Tob. Control, http://dx.doi.org/10.1136/ tobaccocontrol-2016-053014.