Fontem Ventures, a branch of Imperial Tobacco Group PLC, recently renamed Imperial Brands, and the owner of the e-cigarette Blu, announced that it has developed, in partnership with the Austrian company IONICON Analytik GmbH, an online analysis system for the volatile organic compounds (VOCs) present in e-cigarettes aerosols.
The analytical method is based on proton transfer reaction mass spectrometry (PTR-MS) and may apply to both inhalation and exhalation experiments. Compared to the traditional methods based on Gas Chromatography (GC) and high-pressure liquid chromatography (HPLC), the technology they developed allows a fast near-realtime determination of VOCs, and “allows a broad variety of online puff-by-puff e-cigarette studies to be conducted”, indicates Dr O’Connell. The researcher also emphasizes the importance of their approach for the evaluation of e-cigarettes from both a consumer and a bystander perspective.
An important step is highlighted by the paper with the development of a versatile smoking machine that performs a double-stage dilution that, coupled to the very precise and accurate PTR mass spectrometer, expands the dynamic range of measurements to concentrations that cover mainstream emissions but also mouth-hold exhalation and exhaled breath after inhalation, from 2 ppbv (particle per billion in volume) to 1,100 ppmv (particle per million in volume).
The PTR-MS analytical device that allows determining a broad variety of chemicals, was calibrated for the determination of the main components of the e-cigarette aerosols, Propylene Glycol (PG), Vegetal (vegetable) glycerin (VG) and nicotine. Acetaldehyde, acetone, acrolein, methanol and acetonitrile had been screened in e-cigarette emissions by a research team of the University of Irvine, CA with a similar setup but did not address PG, VG and nicotine. More recently, The Swiss Federal Institute of Technology in Zurich, established protocols to investigate the vapor produced by e-cigarettes in real-time with another type of high resolution mass spectrometric technique, the SESI-HRMS.
Such studies are particularly important to explore the potentials of new generations of e-cigarettes in a exponentially growing market. The most recent setups that are preferentially used by experienced vapers are associated to substantial changes in vaping patterns on the individual basis that remain to be evaluated in terms of public health safety.
At the same time as the Fontem Ventures’ paper was published, the independent researcher Konstantinos Farsalinos and his team were granted an official press statement by the prestigious medical journal Addiction for their efforts in setting up a method for testing consistency in nicotine delivery from e-cigarettes, a protocol that is proposed as a reference for the European homologation process. The French standards organization AFNOR and the European Commitee for Standardization (CEN), are very active in the domain of the electronic cigarette. We mentioned a few weeks ago the appointment of Riccardo Polosa at the head of a workgroup on emissions and the publication in the official journal of notification forms on e-cigarettes.
All above studies demonstrate that in the current European regulatory framework of the TPD, the race is on to establish standards. Will the combination of expertise between the private and public sectors be beneficial to the consumer? This is what European vapers expect but will they be heard beyond the commercial aspect?
 Breiev K., Burseg KMM, O’Connell G., Hartungen E., Biel SS., Cahours X., Colard S., Märk TD, Sulzer P. An online method for the analysis of volatile organic compounds in electronic cigarette aerosol based on proton transfer reaction mass spectrometry.Rapid Commun. Mass Spectrom. 2016, 30, 691–697. DOI: 10.1002/rcm.7487
 O’Connell G, Wilkinson P, Burseg KMM, Stotesbury SJ, Pritchard JD (2015) Heated Tobacco Products Create Side-Stream Emissions: Implications for Regulation. J Environ Anal Chem, 2: 163.